Chaperonin–Dendrimer Conjugates for siRNA Delivery
نویسندگان
چکیده
منابع مشابه
Chaperonin–Dendrimer Conjugates for siRNA Delivery
The group II chaperonin thermosome (THS) is a hollow protein nanoparticle that can encapsulate macromolecular guests. Two large pores grant access to the interior of the protein cage. Poly(amidoamine) (PAMAM) is conjugated into THS to act as an anchor for small interfering RNA (siRNA), allowing to load the THS with therapeutic payload. THS-PAMAM protects siRNA from degradation by RNase A and tr...
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Since the discovery of the "starburst polymer", later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2016
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.201600046